Skip to main content

ALL ABOUT MS Treatment (Part 9)

ALL ABOUT MS  Treatment (Part 9)

Glatiramer acetate (Copaxone)

This drug has similar effects and indications as interferon beta but a slightly different mechanism of action. It is applied at a dose of 20 mg, daily, subcutaneously. Side effects are also somewhat different, and include skin changes at the drug site and transient and short-term feeling of tightness in the chest with heart palpitations and a sense of lack of air.

Natalizumab (Tysabri)

This medicine is administered intravenously once a month. It works by preventing the immune system's entry into the brain and thus reducing the inflammatory (inflammatory) effect of immune cells on the nerve cells. Clinical trials have shown that natalizumab significantly reduces the incidence of attacks in the relapse form of MS, but in three patients it has caused a rare, but often fatal, brain disease. After this, the drug was withdrawn from the market, but in 2006 it was returned because of its positive effects on patients with MS. Now, the use of natalizumab is advised under strictly controlled conditions, and only in patients who do not respond positively to any other therapy.

Mitoxantrone (Novantrone)

Mitoxantron is a cytostatic (used in chemotherapy of many types of cancers), which is used in small doses to treat aggressive forms of relapse-remotent form of MS and certain forms of progressive form of MS. It is administered intravenously, every three months. Since mitoxantrone can cause serious side effects after prolonged use, such as heart failure, does not apply for more than two to three years.

Some doctors prescribe some other chemotherapeutic drugs, such as cyclofosfamide (Cytoxan), in the event of a serious, rapidly progressing disease. However, this drug has not been approved by the World Drug Treatment Agency for MS.

Plasmafereza


Plasmafereza is a method that successfully treats autoimmune diseases. However, it is not yet clear whether its use results in short-term or long-term results in MS treatment, and its use is still contested. Plasmapheresis can help restore neurological functions in patients with sudden severe attacks that do not respond to high-dose steroids.

Comments

Popular posts from this blog

Corticosteroids and MS (Part 1)

Corticosteroids and MS (Part 1) Each of us has been treated with Cortisteroids, and Corticosterioids have been used in the treatment of MS since 1950, and today they are the treatment therapy in the treatment of relapse of the disease. The main goal of treatment emergent functional recovery of neurological deficits and prevent the accumulation of neurological deficits that are acquired during an acute exacerbation. With this introduction, they surely started moving your questions around the head. So let's go.
What are corticosteroids?
Corticosteroids are drugs we call steroid hormones. They are synthetically produced hormones and used to treat various pathological conditions in humans. They share glucocorticoids and Mineralocorticoids, and a primitive glucocorticoid is a cortisol that glows the adrenal gland. They can be applied locally as an aerosol-inhalable, skin cream, eye drops or nose, given as tablets, locally into the common space, intravenously and intramuscularly. Drugs from …

ALL ABOUT MS Treatment (Part 11)

Treatment of relapse and some symptoms
Routine therapy for acute relapses is an intravenous high dose of corticosteroids, usually methylprednisolone at a dose of 500 to 1000 mg daily for three to five days. The aim of this therapy is to stop the attack as soon as possible in order to keep as little a consequence of this attack. Although generally effective in short-term symptom relief, corticosteroids do not have a significant impact on long-term recovery. In addition, longer therapy with corticosteroids can lead to osteoporosis, high blood pressure, psychotic reactions, convulsions, and cataracts.
Spasticity, which can be manifested as a permanent contraction caused by an increased muscle tone or transient spasm, is usually treated with muscle relaxants and mitralants such as baclofen, tizanidine, diazepam, clonazepam, and dantrolene. Physical therapy and exercises help preserve existing functions, while various aids, such as a walkway, a stick and a prosthesis, serve to keep the patie…

Food Sustainability

Food Sustainability
When we go to the procurement, we need to carefully select the type of food we buy, and it is very important to check the shelf life, or the date of production, in order to prevent possible negative health consequences. Here are some of the most common questions about food sustainability.


What does the term of food lasts and what is the sustainability of certain foods? The shelf life is the minimum shelf life, the date by which the food retains its characteristic properties if properly stored. Food sustainability depends on the composition, the technological process of production, the sterilization process, the food additives, the type of packaging, the transport and the recommended manner of storage. Some foods are more susceptible to microbiological deterioration and have a short shelf-life. Such products are milk products, creams, shames, ice creams, meat and meat products, eggs. Other foods are subject to chemical changes, especially under the influence of air, an…